Jaizani's television debut was in a 2014 episode of Tyrant. She starred as Sophie in the television series Versailles from 2015 to 2018, and she portrayed Odessa in the series Into the Badlands in 2017.
On March 7, 2019, Jaizani was cast as Bess in Nancy Drew.
- Deadline: The CW’s Nancy Drew Pilot Casts Maddison Jaizani & Alex Saxon. March 7, 2019.